Sadler

BigY3: IN42306
MDKA Birth: England

Tree Position

A0-T-YP2191 > P305[A1] > A1b > BT/A1b2 > M168/PF1416[CT] > P143[CF] > M89/PF2746[F] > F1329/M3658[GHI > F929[HIJK] > IJK > K > M526[K2] > P295[P] > M207[R] > M173[R1] > L146/M420[R1a] > M459 > M198 > M417 > Z645 > Z283 > Z282 > Y2395 > Z284 > S4458 > S5301 > S5153 > S3449 > 13206634-T-A

Unique Mutations

The mutations unique to this man are summarized in the table below. Those with a '+' or '*' confidence level are considered by FamilyTreeDNA or FullGenomesCorp to be high quality SNPs/INDELs. For completeness, all other mutations of lesser confidence are included as well. These additional mutations may be useful for distinguishing between very closely related men.

Occasionally, some of the mutations listed here will be thought to be shared with other men in which case they might appear in upstream blocks on the tree. When this happens, the 'Blocks' field will indicate what block they appear in. Such a situation might arise with BigY men if the BED data suggests another man may be positive for a SNP, even though it doesn't appear in his VCF data. It might also happen if Chromo2 testing or Sanger sequencing of other men not on the tree show the SNP to be shared.

POS-REF-ALT (hg19) POS-REF-ALT (hg38) Blocks Names Region McDonald BED combBED STRBigY3
IN42306
56831283-C-A A*
5483717-A-G 5615676-A-G A*
8426426-C-CTTA 8558385-C-CTTA A*
20706301-C-T 18544415-C-T P4_Prx A*
22422319-C-T 20260433-C-T DYZ19 A*
21176998-G-A 19015112-G-A FT151457 YY+
10093166-C-A 10255557-C-A FT427473 +
10833179-TTTCCA-T +
4113623-A-G 4245582-A-G BY27217 +
4469263-G-A 4601222-G-A FT150509 +
5298266-A-G 5430225-A-G FT150598 +
6537739-T-C 6669698-T-C FT150683 +
7096406-G-T 7228365-G-T FT150729 YY+
7152313-G-A 7284272-G-A FT150734 YY+
7152313-G-GAAA 7284272-G-GAAA +
7331654-A-G 7463613-A-G FT150747 YY+
7510657-G-A 7642616-G-A FT150766 Y+
7642347-A-G 7774306-A-G FT150773 YY+
8557331-T-G 8689290-T-G BY186700 YY+
9771210-C-T 9933601-C-T BY80903 Y+
10664036-C-T FT428504 +
10771393-C-G FT430490 +
16437722-G-T 14325842-G-T BY27223 YY+
16535653-C-T 14423773-C-T FT151199 YY+
17088773-T-G 14976893-T-G FT151244 Y+
17134731-CT-C 15022851-CT-C +
17918151-A-G 15806271-A-G FT151316 YY+
18950749-T-A 16838869-T-A YY+
19137614-G-T 17025734-G-T FT151416 YY+
20808378-AAAG-A 18646492-AAAG-A P4_Gap +
21806423-C-G 19644537-C-G FT151510 Y+
24518712-C-T 22372565-C-T FT51705 +
26320765-T-A 24174618-T-A P1_Y1 +
5502827-C-CTGTGTGTGTG 5634786-C-CTGTGTGTGTG 17×TG*
8426426-C-A 8558385-C-A YY*
22069569-C-T 19907683-C-T FGC8721 Y12870 **
4897781-C-T 5029740-C-T FT322058 **
22489662-A-G 20327776-A-G DYZ19 **
18060345-C-CAT 15948465-C-CAT **
21438179-A-G 19276293-A-G **
13340548-C-T 11184872-C-T **
26329239-A-C 24183092-A-C P1_Y1 **
15081662-C-CT 12969752-C-CT 8×T**
3872628-A-G 4004587-A-G **
5823899-C-G 5955858-C-G **
13294912-T-C 11139236-T-C **
13340530-C-T 11184854-C-T **
13340540-T-G 11184864-T-G **
13745542-A-G 11589866-A-G **
15495231-A-G 13383351-A-G **
16886602-T-C 14774722-T-C **
17466825-T-C 15354945-T-C **
18440414-A-ACG 16328534-A-ACG P6_Dst **
18733595-C-T 16621715-C-T **
22511355-T-C 20349469-T-C DYZ19 **
22692453-A-G 20530567-A-G **
23087502-G-A 20925616-G-A **
13459258-T-C 11303582-T-C ***
19187385-ATTT-A,ATT 17075505-ATTT-A,ATT 28×T***
22973001-A-G 20811115-A-G ***
7084547-G-A 7216506-G-A ***
7101168-A-G 7233127-A-G ***
10859998-T-G ***
7084539-A-G 7216498-A-G ***
4878246-CAAA-C,CAA 5010205-CAAA-C,CAA 18×A***
15093588-CT-C,CTT 12981676-CT-C,CTT 11×T***
56871632-AT-A,T ***
8690208-ATT-A,ATTT 8822167-ATT-A,ATTT 29×T***
28546346-CA-C,CAA 26400199-CA-C,CAA 14×A***
2930379-G-A 3062338-G-A ***
3501955-CAAAAA-C,CAAAAAA 3633914-CAAAAA-C,CAAAAAA 22×A***
3604620-G-A 3736579-G-A ***
3746557-G-T 3878516-G-T ***
5468173-CTTTTTTTTTTTT-C 5600132-CTTTTTTTTTTTT-C 26×T***
6534506-G-A 6666465-G-A ***
8379375-T-A 8511334-T-A ***
13458075-GC-CC,G 11302399-GC-CC,G 9×CATTC***
17446767-CTTTT-C 15334887-CTTTT-C 33×T***
21730548-ATTTT-A,ATTTTT 19568662-ATTTT-A,ATTTTT 23×T***
22253340-GT-G 20091454-GT-G DYZ19 ***
22598200-A-G 20436314-A-G ***
22802868-ATTTTTTTTT-A,AT 20640982-ATTTTTTTTT-A,AT 32×T***
56843800-G-A ***

In the table above, the meaning of the confidence field depends on whether the data comes from an FTDNA kit or an FGC kit. For FTDNA kits, + implies a "PASS" result with just one possible variant, * indicates a "PASS" but with multiple variants, ** indicates "REJECTED" with just a single variant, and *** indicates "REJECTED" with multiple possible variants. 'A*' are heterozygous variants not called by FTDNA, but still pulled from the VCF file. For FGC kits, + indicates over 99% likely genuine (95% for INDELs); * over 95% likely genuine (90% for INDELs); ** about 40% likely genuine; *** about 10% likely genuine. Manual entries read directly from a BAM file will be either + indicating positive, or * indicating that the data show a mixture of possible variants.

For the FTDNA kits, the BED data is encoded in the background color of the cells. Those cells with a white background have coverage, those with a grey background indicate no coverage in the BED file, and those with a pink background indicate the mutation is on the edge of a coverage region. These pink regions often indicate that the individual may be positive for a SNP even if there is no corresponding entry in the vcf file.

The combBED column indicates whether or not the mutation is a SNP and falls in the combBED region defined in Defining a New Rate Constant for Y-Chromosome SNPs based on Full Sequencing Data by Dmitry Adamov, Vladimir Guryanov, Sergey Karzhavin, Vladimir Tagankin, Vadim Urasin.

The McDonald BED column indicates whether or not the mutation is a SNP and falls in the BED region used by Dr. Iain McDonald in the age analysis he does for R-U106 men.