Block Information

Upstream Blocks:

Children:

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Mutations in Block:

Names	Region	Unc	McDonald BED	combBED	POS-ANC-DER (hg19)	POS-ANC-DER (hg38)	Notes
ZZ10							See notes below.
ZZ92							See notes below.

*Mutations whose exact position can't be determined precisely from NGS tests, such as those in palindromes, are shown with a pink background.

The combBED column indicates whether or not the mutation is a SNP and falls in the combBED region defined in Defining a New Rate Constant for Y-Chromosome SNPs based on Full Sequencing Data by Dmitry Adamov, Vladimir Guryanov, Sergey Karzhavin, Vladimir Tagankin, Vadim Urasin, The Russian Journal of Genetic Genealogy (Русская версия), Vol 6, No 2 (2014)/Vol 7, No 1 (2015).

The McDonald BED column indicates whether or not the mutation is a SNP and falls in the BED region used by Dr. Iain McDonald in the age analysis he does for R-U106 men.

Notes:

ZZ10

ZZ10 is a mutation on the P5 palindrome. Because of the similarity of the two arms, current technology can't determine which arm the mutation is on. The two possible mutations are ZZ10_1 and ZZ10_2. A recLOH event could duplicate the mutation to both arms or remove it altogether.

The exact position of this mutation on the Y chromosome is currently unknown. It could be one of several possibilities, including those listed below:

Region	Names	POS-ANC-DER (hg19)	POS-ANC-DER (hg38)
P5_Prx	-	19791668-C-G	17679788-C-G
P5_Dst	-	20388112-G-C	18226226-G-C

In VCF files and other interpretation files, this mutation may appear as any or all of the following possible variants:

Region	Names	POS-REF-ALT (hg19)	POS-REF-ALT (hg38)
P5_Prx	ZZ10_1 ZZ10	19791668-C-G	17679788-C-G
P5_Dst	ZZ10_2	20388112-G-C	18226226-G-C

ZZ92

ZZ92 is a mutation on the P5 palindrome. Because of the similarity of the two arms, current technology can't determine which arm the mutation is on. The two possible mutations are ZZ92_1 and ZZ92_2. A recLOH event could duplicate the mutation to both arms or remove it altogether.

The exact position of this mutation on the Y chromosome is currently unknown. It could be one of several possibilities, including those listed below:

Region	Names	POS-ANC-DER (hg19)	POS-ANC-DER (hg38)
P5_Prx	ZZ92_1	19727508-G-A	17615628-G-A
P5_Dst	ZZ92_2	20452266-C-T	18290380-C-T

In VCF files and other interpretation files, this mutation may appear as any or all of the following possible variants:

Region	Names	POS-REF-ALT (hg19)	POS-REF-ALT (hg38)
P5_Prx	ZZ92_1	19727508-G-A	17615628-G-A
P5_Dst	ZZ92_2	20452266-C-T	18290380-C-T

Haplotype Data

The data below reveals the progression of changes in the haplotype. These are the inferred ancestral haplotypes for various upstream blocks. These inferred haplotypes are a work in progress, and any suggested modifications are appreciated. Mutations made from each upstream block are shown in sequence. The cell color is determined by the block in which the mutation took place.

	DYS393	DYS390	DYS19	DYS391	DYS385	DYS426	DYS388	DYS439	DYS389i	DYS392	DYS389ii	DYS458	DYS459	DYS455	DYS454	DYS447	DYS437	DYS448	DYS449	DYS464	DYS460	Y-GATA-H4	YCAII	DYS456	DYS607	DYS576	DYS570	CDY	DYS442	DYS438	DYS531	DYS578	DYF395S1	DYS590	DYS537	DYS641	DYS472	DYF406S1	DYS511	DYS425	DYS413	DYS557	DYS594	DYS436	DYS490	DYS534	DYS450	DYS444	DYS481	DYS520	DYS446	DYS617	DYS568	DYS487	DYS572	DYS640	DYS492	DYS565	DYS710	DYS485	DYS632	DYS495	DYS540	DYS714	DYS716	DYS717	DYS505	DYS556	DYS549	DYS589	DYS522	DYS494	DYS533	DYS636	DYS575	DYS638	DYS462	DYS452	DYS445	Y-GATA-A10	DYS463	DYS441	Y-GGAAT-1B07	DYS525	DYS712	DYS593	DYS650	DYS532	DYS715	DYS504	DYS513	DYS561	DYS552	DYS726	DYS635	DYS587	DYS643	DYS497	DYS510	DYS434	DYS461	DYS435
P312/S116	13	24	14	11	11-14	12	12	12	13	13	29	17	9-10	11	11	25	15	19	29	15-15-17-17	11	11	19-23	16	15	18	17	36-38	12	12	11	9	15-16	8	10	10	8	10	10	12	23-23	16	10	12	12	15	8	12	22	20	13	12	11	13	11	11	12	12	33	15	9	16	12	26	26	19	12	11	13	12	10	9	12	12	10	11	11	30	12	13	24	13	10	10	20	15	19	13	24	17	12	15	24	12	23	18	10	14	17	9	12	11
L21/S145	13	24	14	11	11-14	12	12	12	13	13	29	17	9-10	11	11	25	15	19	29	15-15-17-17	11	11	19-23	16	15	18	17	36-38	12	12	11	9	15-16	8	10	10	8	10	10	12	23-23	16	10	12	12	15	8	12	22	20	13	12	11	13	11	11	12	12	35	15	9	16	12	25	26	19	12	11	13	12	11	9	12	12	10	11	11	30	12	13	24	13	10	10	20	15	19	13	24	17	12	15	24	12	23	18	10	14	17	9	12	11

The data below are the haplotypes of the immediate descendent blocks and men. There is one row for each downstream block or man who directly descends from this block. Coloring shows the mutations relative to the most immediate available upstream haplotype.

	DYS393	DYS390	DYS19	DYS391	DYS385	DYS426	DYS388	DYS439	DYS389i	DYS392	DYS389ii	DYS458	DYS459	DYS455	DYS454	DYS447	DYS437	DYS448	DYS449	DYS464	DYS460	Y-GATA-H4	YCAII	DYS456	DYS607	DYS576	DYS570	CDY	DYS442	DYS438	DYS531	DYS578	DYF395S1	DYS590	DYS537	DYS641	DYS472	DYF406S1	DYS511	DYS425	DYS413	DYS557	DYS594	DYS436	DYS490	DYS534	DYS450	DYS444	DYS481	DYS520	DYS446	DYS617	DYS568	DYS487	DYS572	DYS640	DYS492	DYS565	DYS710	DYS485	DYS632	DYS495	DYS540	DYS714	DYS716	DYS717	DYS505	DYS556	DYS549	DYS589	DYS522	DYS494	DYS533	DYS636	DYS575	DYS638	DYS462	DYS452	DYS445	Y-GATA-A10	DYS463	DYS441	Y-GGAAT-1B07	DYS525	DYS712	DYS593	DYS650	DYS532	DYS715	DYS504	DYS513	DYS561	DYS552	DYS726	DYS635	DYS587	DYS643	DYS497	DYS510	DYS434	DYS461	DYS435
N3983	13	24	14	11	11-14	13	12	12	14	13	30	18	9-10	11	11	25	15	19	31	15-15-17-17	10	10	19-23	16	15	18	17	36-38	11	12	11	9	15-16	8	10	10	8	10	10	12	23-23	16	10	12	12	15	8	12	23	20	13	13	11	13	11	11	12	12	37	15	9	16	12	25	27	19	12	11	12	12	11	9	13	12	10	11	11	30	12	13	24	13	9	11	20	15	15	15	25	17	12	15	24	12	23	18	10	14	17	9	12	11

Age Analysis - Iain McDonald Method (Work in Progress)

Using the aging method developed by Iain McDonald, the median age of this block is 4057.17 YBP (2108 BC). The 95% confidence interval is 2605 BC to 1667 BC.

Measure	Age (YBP)
Mean	4058.0
Median	4057.2
Mode	4060.0

Age analysis lasted updated 2017-10-03. Only those men and blocks availble at that time were included in the analysis.
Aging parameters: allBED=16833123 allBED2=11039198 iainBED=10196695 iainBED2=8056012 combBED=8415179 combBED2=8152266 adjNumVars=0